Alavijeh, N. S.; Ghabraie, E.; Balalaie, S.
Reactions Involving an α,β-Unsaturated Carbonyl Compound as Electrophilic Component, Cycloadditions, and Boron, Silicon, Free - Radical and Metal - Mediated Reactions
Multicomponent Reaction 2. Thieme Verlag, Stuttgart. Science of Synthesis. 2014.
This chapter describes various multicomponent reactions (MCRs) involving in situ generated
α,β-unsaturated carbonyl compounds formed by Wittig-type reactions.The synthesis of α,β -unsaturated
carbonyl compounds is of great importance as this bifunctional unit is a key structural component
in a variety of naturally occurring and biologically essential substances. Moreover, due to their
high reactivity toward nucleophiles, α,β -unsaturated ketones are very valuable intermediates in
the synthesis of pharmaceutical compounds, natural products, and other functional substances.
α,β –Unsaturated carbonyl compounds have been synthesized using various methods based on the
formation of the C=C bond and, among these methods, Wittig-type reactions still occupy a prominent
position. Wittig reactions involve the synthesis of an alkene by reaction of a carbonyl compound
(aldehyde or ketone) with a phosphonium ylide, via either a betaine and/or an oxaphosphetane intermediate.